Preclinical Studies

TBPL provides In vivo efficacy and pre-clinical safety studies for chemical entities. The Laboratory Animal Services (LAS) Facility of TBPL is registered with the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) and conforms to its guidelines on developing reliable and reproducible scientific data while maintaining a healthy balance between animal ethics, welfare and experimentation.

LAS has established a state-of-the-art, barrier-maintained animal facility for breeding and experimentation on small animals to meet internal, as well as client needs and it is the facility designed to perform experiments on Pharmacology and Toxicology.

TOXICITY STUDIES

For evaluation of the safety levels of drug prior to clinical trials for human use we conduct:

• Acute Toxicity
• Sub-acute Toxicity (Repeated Dose)
• Sub chronic And Chronic Exposure
• In Vitro Biocompatibility Studies
• In Vivo Absorption Studies
• Hematology
• Biochemistry
• Urine analysis
• Histopathology
• Microbiology

LOCAL TOLERANCE STUDIES

• Primary Skin Irritation and Sensitization
• Reproductive Toxicity
• Safety Pharmacology
• Eye Irritation / Corrosion